Marie Yang O'Brien

Scientific Expert – Vaccines & Translational Research

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Marie Yang O'Brien is a seasoned scientific expert in vaccines and translational research with deep experience across biotech, pharma, and global health initiatives. Her expertise spans from early research and preclinical development to clinical translation, particularly in the context of innovative vaccine platforms and infectious disease prevention. She has worked in leadership roles bridging scientific innovation and program execution, with a focus on the development of immunomodulatory compounds (adjuvants) and bacterial vaccines.

Marie has led and contributed to several high-impact vaccine initiatives, leveraging reverse vaccinology to design next-generation, universal vaccines targeting WHO priority pathogens. She has worked closely with global public health agencies and product development partnerships, where she helped translate early-stage immunological concepts into viable clinical candidates. Her career includes scientific leadership in translational immunology, immunoassay development, and immunogen design, as well as oversight of preclinical research teams.

Known for her cross-functional approach, Marie is skilled in aligning scientific programs with regulatory and access pathways, ensuring readiness for downstream development. Her background combines rigorous scientific training with strong collaborative and communication skills, enabling her to lead complex, multi-partner projects from ideation through early clinical development.

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